G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition

RESULTS: We were able to map 16876 genes, from which 2035 changed their expression values at least two fold when we compared SNL to Sham operated (p= 0.01). There were 1205 upregulated and 832 down-regulated genes. Next, we focused on genes whose expression was either up or down-regulated 2 fold due to nerve ligation, and the values would be normalized to control level after G9a/GLP inhibito (UNC0638)r treatment. We identified 639 genes in our data set that behave this way结果：本研究共完成16876个基因的表达谱映射，其中脊神经结扎组（spinal nerve ligation, SNL）与假手术组（sham-operated, Sham）相比，有2035个基因的表达量至少发生2倍变化（p=0.01）。该差异基因包含上调基因1205个、下调基因832个。随后，我们聚焦于因神经结扎导致表达量发生2倍变化的基因，且经G9a/GLP抑制剂（UNC0638）处理后，此类基因的表达值可归一化至对照水平。本数据集中共鉴定出639个符合该特征的基因。