Transcriptome of Nkx2-5-null atria

Atrial specific knockout of Nkx2-5 results in hyperplastic atria with ASD and conduction defects. To examine how Nkx2-5 regulates cardiac proliferation at late gestational stages, RNA-seq was performed. Examination of expression profile of 2 Nkx2-5-null atria and 3 controls心房特异性敲除Nkx2-5可诱发伴随房间隔缺损（Atrial Septal Defect, ASD）与传导功能缺陷的增生性心房病变。为探究Nkx2-5在妊娠晚期对心肌细胞增殖的调控作用，本研究开展了RNA测序（RNA-seq）实验。对2例Nkx2-5缺失心房样本与3例对照样本的基因表达谱进行检测分析。