Crystal structure of Keap1 kelch domain in complex with a tetrahydroisoquinoline-based small molecule inhibitor at 1.2A resolution
收藏Protein Data Bank Japan2024-11-27 更新2026-04-19 收录
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Crystal structure of Keap1 kelch domain in complex with a tetrahydroisoquinoline-based small molecule inhibitor at 1.2A resolution Descriptor: (R)-2-(2-((4-methoxyphenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinolin-7-yl)-2-(9-oxo-9H-fluorene-4-carboxamido)acetate, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Narayanan, D, Bach, A, Gajhede, M. Deposit date: 2024-04-23 Release date: 2024-10-30 Last modified: 2024-11-27 Method: X-RAY DIFFRACTION (1.2 Å) Cite: Structure-Guided Conformational Restriction Leading to High-Affinity, Selective, and Cell-Active Tetrahydroisoquinoline-Based Noncovalent Keap1-Nrf2 Inhibitors. J.Med.Chem., 67, 2024
创建时间：
2024-04-23
