File S1 - Trends in Cardiovascular Disease Risk Factors in People with and without Diabetes Mellitus: A Middle Eastern Cohort Study

Supporting tables. Table S1, Baseline characteristics of the participants with and without follow-up in both diabetic and non-diabetic groupsa; Teheran Lipid and Glucose Study (1999–2011) (a values are presented as mean (SD) unless otherwise indicated; b P value for differences between followed vs. not followed subjects; c P value for differences between followed diabetic vs. followed non-diabetic subjects; dformula for calculating LDL-C values as follows: LDL-C (mg/dl) = Non-HDL-C×90% - TG ×10%; FPG, fasting plasma glucose; HDL-C, high-density lipoprotein cholesterol; TGs, triglycerides; TC, total cholesterol; Non-HDL-C, non-high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; WC, waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index). Table S2, Average measures of CVD risk factors in diabetic and non-diabetic male participants in each phase of Teheran Lipid and Glucose Study (1999-2011) (a formula for calculating LDL-C values as follows: LDL-C (mg/dl) = Non-HDL-C×90% - TG ×10%; FPG, fasting plasma glucose; HDL-C, high-density lipoprotein cholesterol; TGs, triglycerides; TC, total cholesterol; Non-HDL-C, non-high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; WC, waist circumference; WHR, waist to hip ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; CI, confidence interval). Table S3, Average measures of CVD risk factors in diabetic and non-diabetic female participants in each phase of Teheran Lipid and Glucose Study (1999–2011) (aformula for calculating LDL-C values as follows: LDL-C (mg/dl) = Non-HDL-C×90% - TG ×10%; FPG, fasting plasma glucose; HDL-C, high-density lipoprotein cholesterol; TGs, triglycerides; TC, total cholesterol; Non-HDL-C, non-high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; WC, waist circumference; WHR, waist to hip ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; CI, confidence interval). Table S4, Age- and sex-adjusted trends of CVD risk factors in diabetic and non-diabetic populations with no CVD events in each phase of Teheran Lipid and Glucose Studya (1999–2011) (aMean levels of cardiovascular risk factors of diabetic and non-diabetic participants was calculated separately with adjustment of related participants age and sex in each phase while the interaction of diabetes status was assessed in a pooled model consisting both diabetic and non-diabetic participants, using Generalized Estimation Equation method; bformula for calculating LDL-C values as follows: LDL-C (mg/dl) = Non-HDL-C×90% - TG ×10%; FPG, fasting plasma glucose; HDL-C, high-density lipoprotein cholesterol; TGs, triglycerides; TC, total cholesterol; Non-HDL-C, non-high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; WC, waist circumference; WHR, waist to hip ratio; SBP, systolic blood pressure; DBP, diastolic blood pressure; BMI, body mass index; CI, confidence interval). Table S5, The percentage of subjects in diabetic and non-diabetic groups without CVD event in any of study phases who reached goal levels of lipid measures and blood pressure and trends of obesity and different medications consumptiona; Teheran Lipid and Glucose Study (1999–2011) (aThe percentage of cardiovascular risk factors of diabetic and non-diabetic participants was calculated separately with adjustment of related participants' age in each phase while the interaction of diabetes status was assessed in a pooled model consisting both diabetic and non-diabetic participants, using Generalized Estimation Equation method. Goal of hypertension is defined as 1.04 mmol/L for men and >1.29 mmol/L for women in both diabetic and non-diabetic population. Goal of Triglycerides is defined as 2.Abdominal obesity is defined as, WC ≧95 cm in both genders; bformula for calculating LDL-C values as follows: LDL-C (mg/dl) = Non-HDL-C×90% - TG ×10%; HDL-C, high-density lipoprotein cholesterol; TGs, triglycerides; Non-HDL-C, non-high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; BMI, body mass index; WC, waist circumference). (DOC)