Oral Delivery of Propofol with Methoxymethylphosphonic Acid as the Delivery Vehicle
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https://figshare.com/articles/dataset/Oral_Delivery_of_Propofol_with_Methoxymethyl_phosphonic_Acid_as_the_Delivery_Vehicle/5492878
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资源简介：
Phosphonamidate 3a of methoxymethylphosphonic
acid (MMPA) with propofol (1) and l-alanine
ethyl ester was found to be an efficient scaffold for the oral delivery
of compound 1. The synthesis and evaluation of MMPA based
phosphonamidates of compound 1, HSK3486 (2), and other phenolic drugs revealed the general application of MMPA
as the effective delivery vehicle for phenolic drugs. On the basis
of plasma concentrations of compound 1 and SN38 (14), the oral bioavailability of compound 3a and 15 in beagle dogs was found to be 97.6% and 34.1%, respectively.
创建时间：
2017-10-12
