Plebeia catamarcensis and Tetragonisca fiebrigi (Hymenoptera, Apidae) propolis promotes longevity and anti-Alzheimer effects in Caenorhabditis elegans

Alzheimer's disease is a neurodegenerative condition associated with oxidative stress, affecting millions of people worldwide, with expected increases due to the aging population. The development of efficient therapies is still challenging. Propolis, with its antioxidant properties, shows potential in controlling the oxidative stress associated with the disease. The present study aimed to determine the chemical composition of ethanolic extract from propolis produced by Plebeia catamarcensis (EEP-Pc) and Tetragonisca fiebrigi (EEP-Tf), as well as their in vitro and in vivo antioxidant effects, lifespan influence and induced paralysis in Caenorhabditis elegans, mutant model for Alzheimer’s disease.