Nucleotide and amino acid changes and in vivo phenotypes of mip1 mutants.

aThe position of the nucleotide change in MIP1 coding sequence is given.bPosition of the equivalent amino acid in human pol γ sequence.cThe average of the median values (fold increase: ↑ and fold decrease: ↓) is reported to wild-type values arbitrarily set to 1. On average, the frequencies of ER colonies in the MSH1 MIP1 and msh1-1 MIP1 strains were 3×10−8 and 140×10−8, respectively.dOnly one set of at least 15 independent cytoductant cultures was carried out.eRelative exonuclease to polymerase activity ratios are given based on the data of Figure 6. Wild-type ratio has been normalized to 1.