The median values of the PK parameter estimates of VPA in the final population PK models obtained using the NONMEM program and the bootstrap analysis.

VPA = valproic acid; PK = pharmacokinetic; NONMEM = nonlinear mixed-effect model; CIs = confidence intervals; ALAG = absorption lag time; Ka = absorption rate constant; Vd/F = volume of distribution; CL/F = apparent oral clearance; Dose = daily dose of VPA; CBZ = carbamazepine; CLB = clobazam; GBP = gabapentine; PB = phenobarbital; PHT = phenytoin; ω = coefficient of variation of inter-individual variability; σ = coefficient of variation of intra-individual variability; – = data not available. The median values of the PK parameter estimates of VPA in the final population PK models obtained using the NONMEM program and the bootstrap analysis.