Gene expression changes and DNA damage after ex vivo exposure of peripheral blood cells to variable CT photon spectra

In this study, we display traceable impact of energetically-varying CT irradiation on gene regulation with common upregulation of five radiation-responsive genes after single-energy (80 kV or 150kV) and dual-energy CT (80kV + 150kV) exposure. Furthermore, no evdidence for an elevated radiobiological effectiveness in respect to transcriptional impact of low energy photons emitted during dual-energy CT was found. Overall design: Analysis of RNA-Seq changes after single-energy CT- and dual-energy CT-exposure in peripheral human blood cells.