Endothelial Differentiation of CCM1 Knockout iPSCs Triggers the Establishment of a Specific Gene Expression Signature

We used RNA-seq to study the effect of CRISPR/Cas9-mediated CCM1 knockout in induced pluripotent stem cells (CCM1-/- iPSCs), iPSC-derived early mesoderm progenitor and endothelial-like cells (ePMCs and ECs). Comparative gene expression profiling analysis of RNA-seq data for wild-type and CCM1 knockout hiPSCs, early mesodermal progenitor cells and endothelial cells with 3 biological replicates each