Chromatin and tissue plasticity precede commitment to intestinal differentiation during endoderm development

Intestinal differentiation during endoderm development We used RNA-sequencing to profile gene expression changes during the embryonic development of the gastrointestinal tract. ATAC-seq, RNA-seq and CDX2 ChIP-Seq analysis of purified mouse embryonic epithelial cells from the developing mouse gastrointestinal tract.内胚层发育过程中的肠道分化 本研究采用RNA测序（RNA-sequencing）技术，对胃肠道胚胎发育过程中的基因表达变化进行表达谱分析。此外，本研究针对取自发育中小鼠胃肠道的纯化小鼠胚胎上皮细胞，开展了转座酶可及性测序（ATAC-seq）、RNA-seq以及CDX2染色质免疫沉淀测序（ChIP-Seq）分析。