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We investigated the gene expression changes in a library of small cell lung carcinoma (SCLC) patient-derived xenograft (PDX) models.
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创建时间：
2023-10-13
相关数据集
Effects of loss of LSD1 activity on small cell lung cancer cell lines via pharmacological inhibition
To investigate the effects of loss of LSD1 (KDM1A) on differential gene expression, we treated two cell lines of small cell lung cancer with 1??M LSD1 inhibitor ORY-1001 or vehicle control for 10 days
NIAID Data Ecosystem80
miRNA expression profile of SCLC cell lines vs. normal lung. Homo sapiens
Aim: To determine the miRNA expression profile of SCLC cell lines vs. normal lung tissue. Keywords: disease state analysis Overall design: Total RNA isolated from SCLC cell lines H69, HTB-172, HTB-173
NIAID Data Ecosystem30
MicroRNA analysis of Lu134A cells following ASCL1 knockdown. MicroRNA analysis of Lu134A cells following ASCL1 knockdown
Molecular subtypes of SCLC have been defined by the expression status of ASCL1, NEUROD1, YAP1, and POU2F3 transcription regulators. ASCL1 knockdown resulted in decreased and increased expression of mi
NIAID Data Ecosystem20
Expression and role of the receptor tyrosine kinase-like orphan receptor2 (ROR2) in small cell lung cancer. Expression and role of the receptor tyrosine kinase-like orphan receptor2 (ROR2) in small cell lung cancer
Heterogeneity of ROR2 was observed in the tumor tissues form patient-derived xenograft (PDX) model of SCLC, in which the cells with high ROR2 expression (ROR2high cell) and those without ROR2 expressi
NIAID Data Ecosystem30
Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy [RNA-seq]. Neuroendocrine lineage commitment of small cell lung cancers can be leveraged into p53-independent non-cytotoxic therapy [RNA-seq]
Small cell lung cancers (SCLC) rapidly resist cytotoxic chemotherapy and immune-checkpoint inhibitor (ICI) treatments. New, non-cross-resistant therapies are thus needed. SCLC cells are committed into
NIAID Data Ecosystem30
