mouse gut metagenome Raw sequence reads

Although antibiotics are central to the treatment of bacterial infections, their use causes significant disturbances in the gut microbiota and development of antibiotic resistance. Thus, innovative administration methods for delivering antibiotics that avoid side effects on microbiota are urgently needed. Here, we report a positive lipid-assisted polymeric vesicular nanocarrier with a glucosylated surface (Positive Glucosylated Nanoparticles, PGNPs) that facilitates targeted absorption of antibiotics in the proximal small intestine by exploiting the highly specific expression of the sodium-dependent glucose transporter 1 (SGLT1) protein. We show that PGNPs-loaded antibiotics (PGNPs-Abx) effectively eliminated Streptococcus pneumoniae infection in lung