Summary statistics for "Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's Disease"

These are the burden test results (summary statistics) for the publication:

"Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s Disease",

Nature Genetics, 2022.

Format: tab-separated-value.

Fields:

gene_stable_id: Ensembl gene id

gene_name: standard gene name

pvalue: burden test significance (likelihood ratio test, population structure correction based on 6 PCA components)

cmac_all: sum of minor allele dosages across all contributing samples and variants

group: variant group (LOF, LOF+REVEL>=75, LOF+REVEL>=50, LOF+REVEL>=25, see publication methods for further selection criteria).

beta/se: beta/se of logistic ordinal regression (see publication methods). Positive = risk-increasing. Negative = risk-decreasing.