Does early treatment of PKU patients with sapropterin dihydrochloride affect brain development?

We show deleterious effects of SD on developing brain cells in a rat in vitro model. This observation raises the question whether the use of SD can be recommended in very young PKU patients as currently licensed.本研究在大鼠体外模型中证实了SD对发育中脑细胞的有害作用。这一观察结果提出了一个疑问：按照当前获批的用法，SD是否可推荐用于极年幼的苯丙酮尿症（Phenylketonuria）患者？