METHOD. Effects of a personalised nutrition programme on cardiometabolic health: a randomised controlled trial.

Large variability exists in people's responses to foods. A randomised controlled trial was conducted to investigate the impact of a personalised dietary programme (intervention) in comparison general advice (control) on cardiometabolic health. The personalised dietary programme used food characteristics, individual postprandial glucose and triglyceride responses to foods, microbiomes, and health history, to produce personalised food scores in an 18-week app-based programme. The control group received standard care dietary advice (USDA Guidelines for Americans, 2020-2025) using online resources, check-ins, video lessons and a leaflet. Primary outcomes were serum low-density lipoprotein cholesterol (LDL-C) and triglyceride concentrations at baseline and 18-weeks. ClinicalTrials.gov identifier: NCT05273268.