Crystal structure of Syk catalytic domain in complex with a furo[3,2-d]pyrimidine
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Crystal structure of Syk catalytic domain in complex with a furo[3,2-d]pyrimidine Descriptor: N~4~-cyclopropyl-N~2~-(3-methyl-1H-indazol-6-yl)furo[3,2-d]pyrimidine-2,4-diamine, Tyrosine-protein kinase SYK Authors: Argiriadi, M.A, Hoemann, M, Wilson, N, Banach, D, Burchat, A, Calderwood, D, Clapham, B, Cox, P, Duignan, D.B, Konopacki, D, Somal, G, Vasudevan, A. Deposit date: 2016-09-01 Release date: 2016-10-26 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.93 Å) Cite: Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors. Bioorg. Med. Chem. Lett., 26, 2016
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2016-09-01
