Crystal structure of thrombin in complex with a novel glucose-conjugated potent inhibitor
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Crystal structure of thrombin in complex with a novel glucose-conjugated potent inhibitor Descriptor: DIMETHYL SULFOXIDE, Hirudin variant-2, N-(2-{[5-(5-chlorothiophen-2-yl)-1,2-oxazol-3-yl]methoxy}-6-{3-[(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)oxy]propoxy}phenyl)-1-(propan-2-yl)piperidine-4-carboxamide, ... Authors: Belviso, B.D, Caliandro, R, Aresta, B.M, De Candia, M, Altomare, C.D. Deposit date: 2017-10-09 Release date: 2017-12-13 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.84 Å) Cite: How a beta-D-glucoside side chain enhances binding affinity to thrombin of inhibitors bearing 2-chlorothiophene as P1 moiety: crystallography, fragment deconstruction study, and evaluation of antithrombotic properties. J. Med. Chem., 57, 2014
创建时间：
2017-10-09
