Nervous system development related gene expression regulation in the zebrafish embryo after exposure to valproic acid and retinoic acid: a genome wide approach

In our search for biomarkers of maldevelopment, we focused on chemically-induced perturbation of the retinoic acid signaling pathway (RA-SP), a major pathway implicated in a plethora of developmental processes. A genome-wide expression screening was was performed on zebrafish embryos treated with two teratogens, all-trans retinoic acid (ATRA) and valproic acid (VPA), and a negative control, folic acid (FA). Comparative transcriptome analyses between Control, teratogen (all-trans retinoic acid and valproic acid) and negative control (folic acid) Exposition realised for 4 hrs from 3 hours post fertilisation to 7hpf ***RAW data not provided***