Engraftment of aging-related human gut microbiota and the effect of a seven-species consortium in a pre-clinical model

Human aging is characterized by gut microbiome alterations and differential taxa loss linked to healthy aging. The administration of cultured commensal strains might be efficacious for promoting healthy aging. To investigate the interaction of whole microbiomes and administered strains, we transplanted gut microbiota from frail or healthy elderly subjects into germ-free mice.