Changes in Expressions of Spermatogenic Marker Genes and Spermatogenic Cell Population Caused by Stress

Conclusions: Our study suggest that chronic psychosomatic stress can affect the spermatogenic transcriptome of the testes, leading to a significant change in the expression of the spermatogenic genes. At the same time, histopathological and immunohistochemical results showed that chronic stress may lead to pathological changes in spermatogenic cells and to a significant decrease in key regulatory proteins结论：本研究表明，慢性心身应激可影响睾丸的生精转录组（spermatogenic transcriptome），进而导致生精基因的表达发生显著改变。与此同时，组织病理学与免疫组织化学结果显示，慢性应激可引发生精细胞出现病理改变，并使关键调控蛋白的表达量显著降低。