p-MII:SAG dissociates to p-RHO and SAG
收藏reactome.org2025-01-15 收录
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Loss of all-trans-retinal (atRAL) is followed by dissociation of arrestin (SAG) from p-RHO. RHO is then available for covalent binding to 11-cis-retinal (11cRAL), supplied by the retinal pigment epithelium, to regenerate rhodopsin. SAG is capable of binding weakly to rhodopsin, so the dissociation in some rhodopsins may occur after regeneration (Baumann & Bender 1973).
全反式视黄醛(atRAL)的丧失导致逮捕素(SAG)与p-RHO的解离。随后,RHO得以与由视网膜色素上皮提供的11-顺式视黄醛(11cRAL)共价结合,以再生视紫红质。SAG能够与视紫红质弱结合,因此在某些视紫红质的再生过程中,逮捕素可能发生解离(Baumann & Bender 1973)。
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