The role of vagus nerve in liver physiology

Liver metabolism is highly dynamic and is regulated by nutrient availability and humoral factors. A growing body of evidence suggests that the autonomous central nervous system also plays an important role in coordinating hepatic metabolic functions, which confer the flexibility needed for adaptation to fed and fasting states. Because the vagus nerve is the major source of autonomic innervation to the gastrointestinal tract, including the liver, we investigated the role of gal innervation in the proteomic profile of the liver.