Luo1994_CardiacVentricularActionPotential

This a model from the article:
A dynamic model of the cardiac ventricular action potential. I. Simulations of
ionic currents and concentration changes.

Luo CH, Rudy Y. Circ Res
1994 Jun;74(6):1071-96 7514509
,
Abstract:

A mathematical model of the cardiac ventricular action potential is presented.
In our previous work, the membrane Na+ current and K+ currents were formulated.
The present article focuses on processes that regulate intracellular Ca2+ and
depend on its concentration. The model presented here for the mammalian
ventricular action potential is based mostly on the guinea pig ventricular cell.
However, it provides the framework for modeling other types of ventricular cells
with appropriate modifications made to account for species differences. The
following processes are formulated: Ca2+ current through the L-type channel
(ICa), the Na(+)-Ca2+ exchanger, Ca2+ release and uptake by the sarcoplasmic
reticulum (SR), buffering of Ca2+ in the SR and in the myoplasm, a Ca2+ pump in
the sarcolemma, the Na(+)-K+ pump, and a nonspecific Ca(2+)-activated membrane
current. Activation of ICa is an order of magnitude faster than in previous
models. Inactivation of ICa depends on both the membrane voltage and [Ca2+]i. SR
is divided into two subcompartments, a network SR (NSR) and a junctional SR
(JSR). Functionally, Ca2+ enters the NSR and translocates to the JSR following a
monoexponential function. Release of Ca2+ occurs at JSR and can be triggered by
two different mechanisms, Ca(2+)-induced Ca2+ release and spontaneous release.
The model provides the basis for the study of arrhythmogenic activity of the
single myocyte including afterdepolarizations and triggered activity. It can
simulate cellular responses under different degrees of Ca2+ overload. Such
simulations are presented in our accompanying article in this issue of
Circulation Research.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Luo CH, Rudy Y. (1994) - version02

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