Molecular analysis of microscopic ezrin dynamics by two-photon FRAP
收藏PubMed Central2002-09-23 更新2026-05-16 收录
下载链接：
https://pmc.ncbi.nlm.nih.gov/articles/PMC130542/
下载链接
链接失效反馈官方服务：
资源简介：
Ezrin plays a key role in coupling signal transduction to cortical cell organization. This actin–membrane linker undergoes a series of conformational changes that modulate its interactions with various partners and its localization in membrane or cytosolic pools. Its mobility and exchange rates within and between these two pools were assessed by two-photon fluorescence recovery after photobleaching in epithelial cell microvilli. Analysis of ezrin mutants with an altered actin-binding site revealed three ezrin membrane states of different mobilities and exchange properties, reflecting sequential association with membrane components and F-actin in the context of a fast overall turnover.
提供机构：
National Academy of Sciences
创建时间：
2002-09-23
