Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging, and inflammation. Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging, and inflammation

RNA-sequencing of a longitudinal comparison of four principal mesenchymal and endothelial stromal cell types (CXCL12-abundant reticular cells, PDGFR-α+ Sca-1+, sinusoidal and arterial endothelial cells), isolated from early postnatal, adult and aged mice. Additional transcriptional profiling of the response of CXCL12-abundant reticular cells and sinusoidal endothelial cells to infection-mimicking agents. Overall design: RNA-sequencing of four FACS-isolated mouse bone marrow stromal cells at different age stages and conditions.