Genetic and Environmental Risk Factors for Hemorrhagic Stroke (GERFHS)

GERFHS is a population-based, case-control study of hemorrhagic stroke in the Greater Cincinnati/Northern Kentucky region. Cases are recruited from within 50 miles of the University of Cincinnati and population-based controls are matched to cases by age (+/- 5 years), race and gender from the same population as cases. All study participants are of self-reported non-Hispanic Caucasian ethnicity and the data show consistency with the principal component projections. The current submission includes genome wide genotyping on a subset of these cases and controls.]]>
Spontaneous intracerebral hemorrhage Age 18 years or older Resident for 6 months within 50 miles of the University of Cincinnati No evidence of trauma, or brain tumor as cause of hemorrhage Ability of the patient or legal representative to provide informed consent ]]>
The study began in 1997 and included both ICH and SAH but in the final iteration, included recruitment of ICH cases alone. Buccal swab DNA was collected through the first two iterations and blood in GERFHS III which included genotyping of white ICH cases and matched controls.]]>