montelukast arrive checklist.docx

This study investigates the protective role of <b>Montelukast</b> in a <b>mouse </b><b>model </b><b>of </b><b>sepsis</b> induced by <b>cecal </b><b>ligation </b><b>and </b><b>puncture (</b><b>CLP)</b>. Mice were divided into four groups: Sham, CLP, CLP + Vehicle, and CLP + Montelukast (administered 1 hour pre-CLP). Outcomes included renal function, <b>renal </b><b>histology</b>, <b>ELISA</b>, <b>qPCR</b> for gene expression, and <b>IHC</b> for protein markers. Statistical analysis was performed using <b>GraphPad </b><b>Prism </b><b>v9.3.1</b>.The data support Montelukast's potential in reducing inflammation and renal damage during renal sepsis.