Hypercapnia during transcatheter aortic valve replacement under monitored anesthesia care

Acute intraoperative hypercapnia and respiratory acidosis, which can occur during monitored anesthesia care (MAC), pose significant cardiopulmonary risks for patients with aortic stenosis presenting for transcatheter aortic valve replacement (TAVR). The goal of the present study is to assess the incidence, risk factors, and impact of intraoperative hypercapnia during MAC for patients undergoing transfemoral TAVR. Data were collected retrospectively from the electronic medical record of 201 consecutive patients with available intraoperative arterial blood gas (ABG) data who underwent percutaneous transfemoral TAVR with MAC using propofol and dexmedetomidine.  ABGs (pH, PaCO2, PaO2) were performed at the start of each case (baseline), immediately prior to valve deployment (ValveDepl), and upon arrival to the Post Anesthesia Care Unit (PACU).  Data was analyzed using Fisher’s Exact Test, unpaired Student’s t test, Wilcoxon rank sum, or univariate linear regression as appropriate ..., It is a retrospective cohort study. The data was acquired via review of patient charts on EHR after IRB approval. Processed with Fisher's exact test, Student's t test, Wilcoxon rank sum, and linear regression as appropriate.
, , # Hypercapnia during transcatheter aortic valve replacement under monitored anesthesia care

[https://doi.org/10.5061/dryad.31zcrjdvj](https://doi.org/10.5061/dryad.31zcrjdvj)

The dataset comprises raw data collected from patient charts, as well as data derived from statistical analysis.

## Description of the file structure

\"TAVR_MAC_data.csv\" contains raw data obtained from patient charts and is the source of data used in statistical analysis.

\"pco2_60.txt\", \"pco2_50.txt\", \"pH_7.2.txt\" compare variables based on pCO2 and pH cutoffs. Categorical variables were reported as counts and percentages, and continuous variables as mean ± SD.  Categorical variables were analyzed with Fisher’s Exact Test.  Continuous variables were analyzed using an unpaired Student’s t test or Wilcoxon rank sum (2-group comparison) as appropriate after being assessed for normality.

\"ALL_MAC_pts.txt\" describes overall statistics of the study, as well as univariate linear regression analyses of predictors/imp..., This research study was approved by our institution's IRB. Written consent was deemed not necessary because it was a retrospective chart review study. The minimum amount of data necessary was collected in a de-identified form (with only age, sex, weight, BMI as identifiers) on an password protected, encrypted computer.