Eating, Sleeping, Consoling for Neonatal Opioid Withdrawal (ESC-NOW) Trial Data (SAS Table) in Eating, Sleeping, Consoling for Neonatal Opioid Withdrawal (ESC-NOW): a Function-Based Assessment and Management Approach

Eating, Sleeping, Consoling for Neonatal Opioid Withdrawal (ESC-NOW) Trial partial data set that supports the primary outcomes, start to 3 month followup (SAS table).
Study Description
ESC-NOW was a cluster-randomized, controlled trial conducted at 26 U.S. hospitals, which enrolled 1305 infants with neonatal opioid withdrawal syndrome (NOWS). At a randomly assigned time, participants transitioned from usual care based on the Finnegan Neonatal Abstinence Scoring Tool (FNAST) to the Eat, Sleep, Console (ESC) approach. The primary outcome was the time from birth until medical readiness for discharge as defined by the trial. The Eat, Sleep, Console care approach significantly decreased the number of days until infants born with NOWS were medically ready for discharge, without increasing specified adverse outcomes. Infants born at 36 weeks’ gestation or more, who had been born at or transferred to a trial site within 60 hours after birth, and were being treated for opioid withdrawal.