Cortical miR-709 links glutamatergic signaling to NREM sleep EEG slow waves in an activity-dependent manner [agilent_cortex_hippocampus]

Micro-RNAs (miRNAs) are key, post-transcriptional regulators of gene expression that have been implicated in a plethora of biological processes. Their role in sleep, however, has received little attention. In this experiment we investigated the effects of sleep deprivation on the cortex and hippocampus miRNA transcriptome. In this experiment we observed different miRNAs being affected by sleep deprivation in the cortex and hippocampus. Eight C57BL/6J male mice (12 weeks old) were used in total, divided in the sleep-drepived group (n=2) and the non-treated control group (n=2) for cortex or hippocampus.