Smoak et al 2025 data set
收藏DataCite Commons2024-12-27 更新2025-04-15 收录
下载链接：
https://dataverse.harvard.edu/citation?persistentId=doi:10.7910/DVN/RYAHYV
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资源简介：
The medial prefrontal cortex (mPFC) plays a critical role in emotional regulation, and its
dysregulation is linked to anxiety disorders. In particular, the prelimbic cortex (PrL) of the mPFC is thought to modulate anxiety-related behaviors, though its precise role remains debated. Here, we used endoscopic in vivo calcium imaging to assess PrL neuronal activity in male and female Sprague-Dawley rats performing in the Elevated Plus Maze (EPM), a widely used task to measure anxiety-like behavior. We found that animals that spent less time in the open arms exhibited higher PrL activity in the open arms, suggesting that heightened PrL activity may reflect greater anxiety or increased avoidance behavior. These results suggest that the PrL may play a role in regulating the emotional response to anxiety-provoking situations, potentially influencing the tolerance for exposure to threatening environments. This dataset contains the data supporting these findings
提供机构：
Harvard Dataverse
创建时间：
2024-12-27
