Berberine for the intestinal metaplasia after endoscopic therapy for early-stage gastric cancer

Interventions: After the study registry, intestinal metaplasia score of gastric corpus upper gastrointestinal endoscopy and gastric biopsy (updated Sydney system) is evaluated, and only cases with 2 or more score continue to the intervention of (1) or (2) by randomized method. The ratio of (1) and (2) is 2:1 with minimization method. In the cases with 1 or less score, the case finish the study.
(1) Berberine group
patients take berberine 100mg three times a day (300mg per day) for 180 days
(2) No medication follow up group
patients don’t take berberine for 180 days;D001599;berberine
Primary outcome(s): Improvement rate of histological intestinal metaplasia in gastric corpus
Definition: In this study, patients with two or more score of intestinal metaplasia score (updated sydney system) in gastric corpus are intervened. After the intervention with berberine group or control group, patients with one or less the score defined as improved. Primary outcome is improvement rate.
Study Design: randomized controlled trial, open(masking not used), no treatment control/standard of care control, parallel assignment, treatment purpose