Epigenetic control of genes and transposable elements [ATAC-seq]
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=76d72e9332943e8b1b9870cfe6d0bc19
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资源简介：
Epigenetic control is an elaborate system the cell uses to control aspects of cell type and gene control. Histones and DNA are chemically modified to signal epigenetic information as to whether a gene is active or inactive, and so maintain cell type stability. Whilst epigenetic control of genes has been explored, the control of the rest of the genome is less well explored. The bulk of DNA and chromatin consists of repetitive elements, not genes, and these TEs must be tightly regulated to provide structure and function for nearby genes and, ultimately, cell type control. In this project we explore the intereaction of epigenetic control factors, and inhibitors, and how perturbation of the epigenetic control system disrupts TE regulation inside embryonic stem cells.
提供机构：
Guangzhou Institutes of Biomedicine and Health (GIBH), CAS
创建时间：
2022-02-20
