Two Distinct Promoter Nucleosome Architectures at Protein-Coding Genes in Yeast

Previous studies indicate that eukaryotic promoters display a stereotypical chromatin landscape characterized by a well-positioned +1 nucleosome near the transcription start site and an upstream -1 nucleosome that together demarcate a nucleosome-free (or depleted) region过往研究表明，真核启动子（eukaryotic promoters）呈现典型的染色质景观（chromatin landscape）：在转录起始位点（transcription start site）附近存在定位精准的+1核小体（nucleosome），其上游分布有-1核小体，二者共同界定出一片核小体缺失（或耗竭）区域（nucleosome-free (or depleted) region）