Structural Plasticity as a Driver of the Maturation of Pro-Interleukin-18

A series of NMR datasets characterizing the dynamics of pro-interleukin-18 on a range of timescales are provided. These include HSQC spectra (wild type and P93T pro-interleukin-18), 15N relaxation (R1rho, R1, 15N-1H heteronuclear NOE, HxNx, HzNx, HxNz, HzNz), methyl 3Q forbidden, CPMG (15N, 1HN, 13CO, methyl 13C MQ, methyl 1H SQ), CEST (15N, 1HN, 13CO, 13Calpha, 13Cbeta, 1Halpha, methyl 13C, methyl 1H), and hydrogen-deuterium exchange (HDX). 15N CPMG and CEST datasets were recorded at 25C, 29C, 32.5C, 35C, and 40C. For additional details refer to the associated publication.