首页/数据集/Interferon regulatory factor 5 expression levels regulate murine lupus in a type-I interferon-independent manner

Interferon regulatory factor 5 expression levels regulate murine lupus in a type-I interferon-independent manner

ChEBI2009-09-09 更新2026-07-21 收录

狼疮疾病模型

IRF5基因表达调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-17926 数据链接链接失效反馈

官方服务：

资源简介：

Interferon regulatory factor 5 expression levels regulate murine lupus in a type-I interferon-independent manner

应用场景：

创建时间：

2009-09-09

相关数据集

IFIT1敲除小鼠

狼疮疾病模型

基因功能研究

干扰素诱导基因(IFN induced gene,ISGs)IFIT1是Ⅰ型干扰素诱导基因家族中表达量最高的基因.已有研究发现SLE患者的外周血IFIT1表达升高,且在狼疮肾炎患者的肾组织中也观察到相同的升高.已有研究证明IFIT1过量表达能够增加炎性因子加重自身免疫,认为IFIT1表达水平升高可作为新的狼疮病情活动候选指标。该品系为利用CRISPR/Cas9技术构建C57BL/6背景的IFIT1

中国科技资源共享网2023-07-23 更新80

Loss of epigenetic modifications on the inactive X chromosome and sex-biased gene expression profiles in B cells from NZB/W F1 mice with lupus-like disease

狼疮疾病模型

性别差异表达

We report loss of epigentic silencing marks on the inactive X on female mice with lupus like disease, and find novel sex differences in gene expression between female and male mice with late stage dis

NIAID Data Ecosystem10

mouse metagenome LAXL

狼疮疾病模型

基因组学分析

mouse metagenome in lupus model

NIAID Data Ecosystem10

BWF1 mice. Mus musculus

狼疮疾病模型

性别差异表达

Goal of experiment: Identification of differentially expressed immune genes from male and female BWF1 lupus-prone mice. (Female incidence is higher than male--attempting to find sex hormone regulated

NIAID Data Ecosystem20

Retinoic acid exerts disease stage-dependent effects on pristane-induced lupus. Retinoic acid exerts disease stage-dependent effects on pristane-induced lupus

狼疮疾病模型

维甲酸研究

We previously showed that all-trans-retinoic acid (tRA), an active metabolite of vitamin A, exacerbated pre-existing autoimmunity in lupus; however, its effects before the development of autoimmunity

NIAID Data Ecosystem10