Cr2

Enables complement receptor activity. Acts upstream of or within with a negative effect on complement activation, alternative pathway. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; immunoglobulin mediated immune response; and skeletal system development. Located in external side of plasma membrane. Is expressed in several structures, including brain; hemolymphoid system; liver; placenta; and yolk sac. Human ortholog(s) of this gene implicated in common variable immunodeficiency 7; nasopharynx carcinoma; and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2). [provided by Alliance of Genome Resources, Nov 2024]

激活补体受体活性。在补体激活的替代途径中，作用于上游或内部，并产生抑制作用。在多个过程中发挥作用，包括细胞对脂多糖的响应；由免疫球蛋白介导的免疫反应；以及骨骼系统的发展。位于质膜的外侧。在多个结构中表达，包括大脑；血液淋巴系统；肝脏；胎盘；和卵黄囊。此基因的人类同源基因与常见变量免疫缺陷7；鼻咽癌；和系统性红斑狼疮有关。与人类CR2（补体C3d受体2）同源。[由基因组资源联盟提供，2024年11月]