Genome-wide QTL mapping across three tissues highlights several Alzheimer's and Parkinson's disease loci potentially acting via DNA methylation: Summary statistics

This dataset contains a full release of summary statistics and other results for the project entitled "Genome-wide QTL mapping across three tissues highlights several Alzheimer's and Parkinson's disease loci potentially acting via DNA methylation". A paper describing this work is available as preprint on medRxiv (https://www.medrxiv.org/content/10.1101/2023.12.22.23300365v1). We kindly request that you cite this preprint in projects utilizing the data posted here. As soon as the manuscript is accepted for publication in a peer-reviewed journal, this dataset description will be updated.

The dataset contains three sets of results:

1) Summary statistics for meQTL GWAS analyses in blood, buccal and saliva tissue (for SNP-CpG pairs with p<1E-14).

2) Results from summary data based Mendelian randomization (SMR) analyses linking the results from #1) with recent risk GWAS for Alzheimer's disease (AD) and Parkinson's disease (PD).

3) Results from two-sample Mendelian randomization (2MR) analyses linking DNAm and risk for AD/PD for loci prioritized in #2).

All genomic positions provided in these files are based on human genome build GRCh37/hg19. For more details on these results and how they were generated, please see the publication referenced above.