LSD1 inhibition promotes epithelial differentiation through derepression of fate- determining transcription factors [ChIP-seq]

We report the impact of the pharmacological inhibition of the Histone 3 Lysine 4 demethylase (H3K4) LSD1 (KDM1A) enzymatic activity on its binding genome wide and how it impacts genome-wide H3K4me1 and H3K4me2 deposition in Normal Human Epidermal Keratinocytes (NHEK) Overall design: Examination of LSD1 (KDM1A) genome-wide binding and H3K4me1/H3K4me2 deposition upon pharmacological inhibition of LSD1 enzymatic activity in normal human epidermal keratinocytes (NHEK) Please note that each processed data was generated from both *4624 and *4625 replicates and is linked to the corresponding *4624 sample records.