Imaging Mass Spectrometry-based Molecular Histology Differentiates Microscopically Identical and Heterogeneous Tumors

Many
tumors display significant cellular heterogeneity as well
as molecular heterogeneity. Sensitive biomarkers that differentiate
between diagnostically challenging tumors must contend with this heterogeneity.
Mass spectrometry-based molecular histology of a patient series of
heterogeneous, microscopically identical bone tumors highlighted the
tumor cell types that could be characterized by a single profile and
led to the identification of specific peptides that differentiate
between the tumors.