Rare variant polygenic scores (rvPRS) are being developed to improve phenotype prediction, yet a standardized construction protocol remains unavailable. We sought to establish an optimal rvPRS pro
We first identified candidate VMRs, defined as regions of CpG-sites showing the highest variability across all methylation sites.To examine the factors that best explain the variance in methylation in
Density-Flow.dat and Density-Velocity.dat are the raw data in Fig. 3 Syn-flow.dat and Syn-density.dat are the raw data in Fig. 4 Meandist.dat, Steplength.dat and Safedist are the raw data in Fig. 5 Sy