Comparison of typical run-times(a) and hit accuracy measured on the prion octapeptide repeat region.

(a)The times were measured for 1,000,000 amplicons harboring different randomly placed substitutions.(b)SNP(1) sequences were produced by placing 1 random substitution in to the repeat region using the MSBAR program of the EMBOSS package [25]. The times were measured for 1,000,000 randomly generated read copies.(c)The times were measured for 1,000,000 copies of the same sequence.(b)http://bioinformatics.bc.edu/marthlab/Mosaik, version 1.1.0014.