Ascl2 acts as an R-spondin/Wnt responsive switch to control stemness in intestinal crypts [ChIP-seq]

ChEBI2016-07-15 更新2026-07-12 收录

Wnt信号通路调控

肠道干细胞表观遗传

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-84456 数据链接链接失效反馈

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资源简介：

Ascl2 acts as an R-spondin/Wnt responsive switch to control stemness in intestinal crypts [ChIP-seq]

创建时间：

2016-07-15

Gene expression in Rspo2 and/or Wnt3a treated C57MG mouse mammary epithelial cells. Mus musculus

Wnt信号通路调控

乳腺上皮细胞基因表达

R-spondins (Rspos) comprise a family of four secreted proteins that have important roles in cell proliferation, cell fate determination and organogenesis. Rspos typically exert their effects by potent

NIAID Data Ecosystem70

I?Ba deficiency imposes a fetal phenotype to intestinal stem cells [ChIP-seq]

肠道干细胞表观遗传

I?Ba缺陷诱导干细胞胎儿样表型

The intestinal epithelium is a paradigm of adult tissue in constant regeneration that is supported by intestinal stem cells (ISCs). The mechanisms regulating ISC homeostasis after injury are poorly un

NIAID Data Ecosystem20

Fighting against promoter DNA hyper-methylation: Protective histone modification profiles of stress-resistant intestinal stem cells [ChIP-Seq]

肠道干细胞表观遗传

辐射应激组蛋白修饰保护

Aberrant DNA methylation in stem cells is a hallmark of aging and tumor development. Recently, we have suggested that promoter DNA hyper-methylation originates in DNA repair and that even successful D

NIAID Data Ecosystem20

Fighting against promoter DNA hyper-methylation: Protective histone modification profiles of stress-resistant intestinal stem cells [RNA-Seq]

肠道干细胞表观遗传

DNA甲基化与组蛋白修饰互作

NIAID Data Ecosystem30

TGFÃ-induced lncRNA LINC00313 activates Wnt signalling and promotes cholangiocarcinoma progression

胆管癌分子机制

Wnt信号通路调控

Cholangiocarcinoma (CCA) is a devastating liver cancer characterized by high aggressiveness and resistance to therapy, which results to poor prognosis. Signals imposed by oncogenic pathways, such as t

NIAID Data Ecosystem20

Ascl2 acts as an R-spondin/Wnt responsive switch to control stemness in intestinal crypts [ChIP-seq]

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