Pathological changes in cynomolgus monkeys after laser-photocoagulation.

LGN: lateral geniculate layer, ONH: optic nerve head, ON: optic nerve, GFAP: glial fibrillary acidic protein, Iba-1: ionized calcium-binding adaptermolecule-1, PBR: peripheral benzodiazepine receptor. Glaucoma stages were classified by histological changes based on the extent of axonal loss as mild (0–20%), moderate (20–50%), and advanced glaucoma (50–100%). Neuronal atrophy, RGC loss and immunoreactivity were classified based on the quantitative data as follows: no changes; −, mild; +, moderate; ++, robust; +++.