Bridging the gap between cellular and whole body imaging using Hierarchical Phase-Contrast Tomography: HiP-CT
收藏ESRF Portal2028-01-01 更新2026-04-23 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-ES-2238172277
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资源简介：
Humans and other large organisms are three-dimensional multiscale biological systems where large scale function and structure are dependent on the macrostructure’s interconnectivity down to the cellular and subcellular level. Using the exceptional coherence provided by the ESRF-EBS, we have demonstrated that propagation-based phase-contrast can effectively decouple resolution from specimen size in soft tissue, obtaining 1.4 micron voxel resolution in 150 mm diameter human organs. Through this Long Term Proposal (LTP) we will develop the techniques required to image whole human and animal bodies ex vivo at 25 micron resolution, zooming to sub-micron voxels (0.7micron) locally, resolving sub-cellular structures through hard- and soft-tissue. Resolving how the micro (sub-cellular) interacts with the macro (whole organism) across length scales will provide all new insights into biological and biomedical function. This is true for both healthy and pathological system level behaviour.
提供机构：
University College London, Department of Mechanical Engineering, Roberts Building, Torrington Place, Wc1e 7je London, United Kingdom; University College London, Department of Mechanical Engineering, Roberts Building Torrington Place, WC1E 7JE, London, UNITED KINGDOM; Amsterdam UMC, University of Amsterdam, Department of Obstetrics & Gynecology, Meibergdreef 9, 1105AZ, Amsterdam, NETHERLANDS
创建时间：
2028-01-01
