SATB1 promotion of trophoblast stem cell renewal

Trophoblast stem (TS) cell renewal and differentiation are essential processes in placentation. Here, we have identified the mechanism/targets of chromatin organizer/transcription factor called special AT-rich binding protein 1 (SATB1) action on TS cell renewal by RNA-seq analysis in Rcho-1 TS cells expressing Satb1 shRNAs.滋养层干细胞（TS细胞）的自我更新与分化是胎盘形成过程中的核心生物学过程。本研究通过在表达Satb1短发夹RNA的Rcho-1滋养层干细胞中开展RNA测序分析，鉴定出了特异性AT富集结合蛋白1（SATB1）——一种染色质组织者/转录因子——在滋养层干细胞自我更新过程中的作用机制与调控靶点。