Transcriptomic evaluation of pediatric localized scleroderma skin with histological and clinical correlation

In this study, we explored enhanced results of RNA transcriptomic expression between pediatric localized scleroderma skin tissue and healthy control skin. Additional histological and clinical comparison of LS patient features with DEGs supports an inflammatory and fibroproliferative grouping demonstrated in unsupervised clustering of the transcriptomic data. Overall design: Comparision between localized scleroderma and healthy controls in bulk sequencing of the skin with histological clinical data