miR-146a-5p Modulates Cellular Senescence and Apoptosis in Visceral Adipose Tissue of Long-Lived Ames Dwarf Mice and in Cultured Pre-Adipocytes

MicroRNAs (miRNAs) are potent regulators of multiple biological processes. Previous studies have demonstrated that miR-146a-5p increases in normal mice during aging, while long-living Ames dwarf (df/df) mice maintain youthful levels of this miRNA. The aim of this study was to elucidate the involvement of miR-146a-5p in modulating cellular senescence and apoptosis in visceral adipose tissue of df/df mice.