Mismatch-repair signature mutations activate gene enhancers across human colorectal cancer epigenomes
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
We show that mismatch-repair (MMR) signature mutations can activate colorectal cancer (CRC)-specific enhancers, through analysis of enhancer DNA associated with the active enhancer histone mark H3K27ac. We demonstrate that MMR mutations activate enhancers using a xenograft metastasis model, where mutations are induced naturally via CRISPR/Cas9 inactivation of MLH1 prior to tumor cell injection.
提供机构：
Case Western Reserve University
创建时间：
2022-02-20
